NLM Mourns Loss of Clifford A. Bachrach, MD, Editor and Division Chief at the National Library of Medicine

The National Library of Medicine (NLM) mourns the loss of physician and researcher Dr. Clifford A. Bachrach, who died of pneumonia at a health care center in Gaithersburg, Maryland on June 16, 2015. He was 98 years old.
Source: NLM General Announcements - Category: Databases & Libraries Source Type: news

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ConclusionWe conclude that low-tidal-volume ventilation may be a potential strategy for the prevention of ventilator induced lung injury in a murine model of systemic TLR agonist induced lung injury.
Source: Life Sciences - Category: Biology Source Type: research
Conclusion: Further studies are needed to compare CTRX and ABPC/SBT treatments in patients with aspiration-associated pneumonia. PMID: 31736321 [PubMed - as supplied by publisher]
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
Condition:   Pneumonia, Pneumococcal Interventions:   Drug: pPCV;   Biological: Pneumovax™23 Sponsor:   Merck Sharp & Dohme Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Respiratory Distress Syndrome;   Pneumonia;   Bronchiolitis;   Croup;   Croup; False;   Asthma;   Bronchial Hyperreactivity Intervention:   Device: Telemedicine Sponsor:   Rijnstate Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Objectives: To perform a comprehensive description of the epidemiology of Streptococcus pyogenes invasive disease in the pediatric population in 2 regions of Spain (Catalonia and Gipuzkoa) through 12 years. Methods: All S. pyogenes isolates causing invasive disease in pediatric patients between 2005 and 2016 were included. The emm-type and the presence of 13 exotoxin genes (speA, speB, speC, speF, speG, speH, speI, speJ, speK, speL, speM, smeZ, ssa and slo) were determined in all 93 available isolates and the Multi Locus Sequece Typing in 10% of isolates of each different emm-type. Results: Overall, 103 cases of S....
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Background: The impact of universal 13-valent pneumococcal conjugate vaccine immunization on pediatric empyema rates and pathogens in Australia is not known. We aimed to describe empyema epidemiology, clinical characteristics and treatment during an 8-year period. Methods: A retrospective study between 2011 and 2018 of empyema cases admitted to a large pediatric referral hospital, for management with either pleural drainage and fibrinolytics or surgical intervention. Results: There were 195 cases in 8 years. Empyema incidence and ICU admission rates significantly increased during the study with a peak incidence of ...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
During my nine years in the NFL, I ruptured tendons in my fingers, suffered multiple concussions, and broke several bones. I tore my ACL, MCL, and PCL, and completely blew out my left knee. That last injury should have ended my career. But it didn’t. I put myself back together and played through the pain. What finally took me down? A tiny bug I had never heard of and couldn’t see. A drug-resistant staph infection called methicillin-resistant Staphylococcus aureus cost me my NFL career—and almost my life. MRSA is one of many deadly, antibiotic-resistant infections. Together, these “superbugs” k...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health Source Type: news
Whether respiratory epithelial cells regulate the final transit of extravasated neutrophils into the inflamed airspace or are a passive barrier is poorly understood. Alveolar epithelial type 1 (AT1) cells, best known for solute transport and gas exchange, have few established immune roles. Epithelial membrane protein 2 (EMP2), a tetraspan protein that promotes recruitment of integrins to lipid rafts, is highly expressed in AT1 cells, but has no known function in lung biology. Here, we show that Emp2–/– mice exhibit reduced neutrophil influx into the airspace after a wide range of inhaled exposures. During bacte...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Condition:   Community-Acquired Pneumonia Interventions:   Drug: Predetermined treatment duration;   Drug: Variable treatment duration Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Solithromycin concentrations in DBS were similar to those measured in LPS and did not require correction for hematocrit or protein binding.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Short Communication Source Type: research
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