Silver-Catalyzed Carbofluorination of Olefins and α-Fluoroolefins with Carbamoyl Radicals

Chemistry. 2024 May 7:e202401419. doi: 10.1002/chem.202401419. Online ahead of print.ABSTRACTThe reactivity of carbamoyl radicals, generated in situ from sodium oxamate salts, has been investigated in the context of radical carbofluorination reactions of olefins and a-fluoroolefins, respectively. Both transformations are catalyzed by silver salts and required the presence of potassium persulfate (K2S2O8) and SelectfluorTM as a radicophilic fluorine source. The reported methods provide a direct access to beta-fluoroamides and beta,beta-difluoroamides.PMID:38712694 | DOI:10.1002/chem.202401419

Source: Chemistry - May 7, 2024 Category: Chemistry Authors: Émilie Vincent Julien Brioche Source Type: research