Nanoarchitectonic Engineering of Thermal ‐Responsive Magnetic Nanorobot Collectives for Intracranial Aneurysm Therapy

A nanorobotic platform engineered to treat intracranial aneurysms (IAs) through rapid and stable embolization by deploying thermal-responsive FTP nanorobots consisting of phase-change material (PCM)-encapsulated magnetite-thrombin (Fe3O4-Th@PCM), which synergistically integrate smart material design, secure drug packaging, agile magnetic actuation, and clinical interventional imaging to circumvent exogenous implant rejection and cumbersome microcatheter shaping for quicker and after IA therapy in clinics. AbstractStent-assisted coiling is a main treatment modality for intracranial aneurysms (IAs) in clinics, but critical challenges remain to be overcome, such as exogenous implant-induced stenosis and reliance on antiplatelet agents. Herein, an endovascular approach is reported for IA therapy without stent grafting or microcatheter shaping, enabled by active delivery of thrombin (Th) to target aneurysms using innovative phase-change material (PCM)-coated magnetite-thrombin (Fe3O4-Th@PCM) FTP nanorobots. The nanorobots are controlled by an integrated actuation system of dynamic torque-force hybrid magnetic fields. With robust intravascular navigation guided by real-time ultrasound imaging, nanorobotic collectives can effectively accumulate and retain in model aneurysms constructed in vivo, followed by controlled release of the encapsulated Th for rapid occlusion of the aneurysm upon melting the protective PCM (thermally responsive in a tunable manner) through focused magnetic h...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research