Facile access to C-substituted piperazin-2-ones and mianserin derivative enabled by chemoselective carbene insertion and cyclization cascade

Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC00959B, CommunicationDharmendra Kumar, Urmila Unnikrishnan, Malleswara Rao Kuram The chemoselective N-H insertion of unsymmetrical diamines into carbene is a longstanding challenge. A simple copper-catalyzed strategy for synthesizing C-substituted piperazinones is described, employing easily accessible diazo compounds and 1,2-diamines.... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Chem. Commun. latest articles - May 6, 2024 Category: Chemistry Authors: Dharmendra Kumar Source Type: research