Clostridioides difficile Colitis

Surg Clin North Am. 2024 Jun;104(3):545-556. doi: 10.1016/j.suc.2023.11.005. Epub 2023 Dec 26.ABSTRACTClostridioides difficile colitis is an important source of hospital-acquired diarrhea associated with antibiotic use. Symptoms are profuse watery diarrhea, typically following a course of antibiotics; however, some cases of fulminant disease may manifest with shock, ileus, or megacolon. Nonfulminant colitis is treated with oral fidaxomicin. C difficile colitis has a high potential for recurrence, and recurrent episodes are also treated with fidaxomicin. Bezlotoxumab is another medication that may be used in populations at high risk for further recurrence. Fulminant disease is treated with maximal medical therapy and early surgical consultation. Antibiotic stewardship is critical to preventing C difficile colitis.PMID:38677819 | DOI:10.1016/j.suc.2023.11.005
Source: The Surgical Clinics of North America - Category: Surgery Authors: Source Type: research