< em > In vitro < /em > activity of gepotidacin and comparator antimicrobials against isolates of nontuberculous mycobacteria (NTM)

Antimicrob Agents Chemother. 2024 Apr 24:e0168423. doi: 10.1128/aac.01684-23. Online ahead of print.ABSTRACTNovel antimicrobials are needed to treat rising nontuberculous mycobacteria (NTM) infections. Using standard broth microdilution methods, 68 NTM isolates were tested against gepotidacin, a new, first-in-class, oral triazaacenaphthylene bacterial topoisomerase inhibitor. MICs varied (0.25 to >64 µg/mL) with the lowest being M. fortuitum complex (0.25-8 µg/mL), M. mucogenicum complex (1-2 µg/mL), M. kansasii (0.25-8 µg/mL), and M. marinum (4-16 µg/mL). Testing greater numbers of some species is suggested to better understand gepotidacin activity against NTM.PMID:38656138 | DOI:10.1128/aac.01684-23

Source: Antimicrobial Agents and Chemotherapy - April 24, 2024 Category: Microbiology Authors: Barbara A Brown-Elliott Georgie Bush M Dolores Hughes Eliana Rodriguez Chase A Weikel Sharon B Min Richard J Wallace Source Type: research