Imaging Monoamine Oxidase B in Inflammatory Illnesses Comorbid With Major Depressive Disorder

Diseases which induce peripheral and central inflammation are frequently comorbid with major depressive disorder (MDD) and comorbidity is associated with treatment resistance. Here we apply state of the art [11C]SL25.1188 PET to measure monoamine oxidase B (MAO-B) VT, marker of astrogliosis in several diseases commonly comorbid with MDD for which specific mechanisms are implicated in inducing peripheral or central inflammation, yet lack investigation of astrogliosis.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jeffrey Meyer, Joeffre Braga, Yuko Koshimori Source Type: research