Organocatalytic access to 3-pyridylphosphonates from vinyl phosphonates and aldehydes

Chem Commun (Camb). 2024 Apr 26. doi: 10.1039/d4cc00131a. Online ahead of print.ABSTRACTThe preparation of 3-phosphorylated pyridines has remained the most challenging compared to the corresponding 2- or 4-functionalized pyridines. Herein, an unprecedented amino-organocatalyzed direct synthesis of 3-pyridylphosphonates from vinylphosphonates and aldehydes has been achieved. This allows access to a wide range of multi-substituted phosphorylated pyridines in excellent yields under transition metal-free conditions.PMID:38666411 | DOI:10.1039/d4cc00131a

Source: Chemical Communications - April 26, 2024 Category: Chemistry Authors: Ram Subhawan Verma Anil Kumar Khatana Deepika Verma Bhoopendra Tiwari Source Type: research