Uterine fluid microRNAs in repeated implantation failure

Clin Chim Acta. 2024 Apr 17:119678. doi: 10.1016/j.cca.2024.119678. Online ahead of print.ABSTRACTRecurrent implantation failure (RIF) is a significant obstacle in assisted reproductive procedures, primarily because of compromised receptivity. As such, there is a need for a dependable and accurate clinical test to evaluate endometrial receptiveness, particularly during embryo transfer. MicroRNAs (miRNAs) have diverse functions in the processes of implantation and pregnancy. Dysregulation of miRNAs results in reproductive diseases such as recurrent implantation failure (RIF). The endometrium secretes several microRNAs (miRNAs) during the implantation period, which could potentially indicate whether the endometrium is suitable for in vitro fertilization (IVF). The goal of this review is to examine endometrial miRNAs as noninvasive biomarkers that successfully predict endometrium receptivity in RIF.PMID:38641194 | DOI:10.1016/j.cca.2024.119678

Source: International Journal of Clinical Chemistry - April 19, 2024 Category: Chemistry Authors: Pourya Rokhsartalab Azar Mahdi Maleki Aghdam Sarmad Karimi Arian Haghtalab Sonia Sadeghpour Hassan Mellatyar Mortaza Taheri-Anganeh Hojat Ghasemnejad-Berenji Source Type: research