Nickel Nanocluster as a Fluorescent Probe for the Non-enzymatic Detection of Cardiac Troponin I

AbstractTroponin I, as a cardiac-specific biomarker, is a very valuable tool in the identification of acute coronary syndromes. In this work, an economical technique for easy and sensitive diagnosis of cardiac troponin I (cTnI) was developed nanoprobe on the basis of graphene oxide quenching of the fluorescence of bovine serum albumin –capped fluorescent nickel (BSA@NiNCs) nanoclusters. The developed nanoprobe nickel nanocluster exhibited superparamagnetism. The nanoprobe showed a fluorescence turn-on behavior toward incremental addition of in cTnI, with a detection limit of 0.012 ng/mL. We successfully used the proposed sensin g technique for cTnI sensing in serum samples.
Source: Plasmonics - Category: Biomedical Science Source Type: research