Local environment in yeast-based impedance biodosimeters strongly influences the measurable dose

Appl Radiat Isot. 2024 Apr 12;209:111323. doi: 10.1016/j.apradiso.2024.111323. Online ahead of print.ABSTRACTThis work investigates the feasibility of yeast-based impedance measurements for retrospective dosimetry applications. The local environment around yeast cells in a previously developed film-badge was modeled using Geant4. A greater dose response was observed when yeast cells were surrounded by an aluminum-polymer structure, which acted as a conversion layer. Bench-top experiments were conducted using a jar-based dosimeter design that directly combined a finely-ground aluminum conversion medium with yeast powder. It was shown when irradiated in the presence of aluminum grains, yeast cells yielded a higher impedance signal, thereby indicating greater radiation-induced damage. Finally, in separate irradiation experiments, lead and aluminum sheets were placed behind yeast samples and the dosimeters were irradiated to 1 Gy. A 2-fold increase in the impedance signal was shown when samples were positioned in close contact with the lead sheet compared to the aluminum sheet. In all experiments, it was shown that the local environment significantly influences radiative energy deposition in yeast cells.PMID:38631246 | DOI:10.1016/j.apradiso.2024.111323
Source: Applied Radiation and Isotopes - Category: Radiology Authors: Source Type: research