Triton B Catalyzed Rapid and Mild Synthetic Protocol for both Henry Reaction of Isatin and Michael Reaction of Chalcone with Nitroalkane

Synlett DOI: 10.1055/s-0043-1774862 A highly efficient and general synthetic protocol for both Henry and Michael reactions was developed using metal-free catalyst Triton B (benzyltrimethylammonium hydroxide) and isatins and chalcones, respectively. This methodology is inexpensive, the reagents are easy to handle, and the approach offers wide functional group tolerance of isatins and chalcones. The base catalyst Triton B is less toxic, recyclable, and reusable. This efficient method reduces reaction times, minimizes reagent excess, avoids chromatography, and is aligned with sustainable chemistry principles, offering eco-friendly applications in diverse industries. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - April 23, 2024 Category: Chemistry Authors: Talukdar, Mrinal Islam, Nasreen Mishra, Akanksha Dave, Alpa Y Begari, Eeshwaraiah Tags: letter Source Type: research