Molecules, Vol. 29, Pages 1874: Synthesis of & omega;-Chloroalkyl Aryl Ketones via C & ndash;C Bond Cleavage of tert-Cycloalkanols with Tetramethylammonium Hypochlorite

Molecules, Vol. 29, Pages 1874: Synthesis of ω-Chloroalkyl Aryl Ketones via C–C Bond Cleavage of tert-Cycloalkanols with Tetramethylammonium Hypochlorite Molecules doi: 10.3390/molecules29081874 Authors: Natsumi Hanazawa Masami Kuriyama Kosuke Yamamoto Osamu Onomura An oxidative C–C bond cleavage of tert-cycloalkanols with tetramethylammonium hypochlorite (TMAOCl) has been developed. TMAOCl is easy to prepare from tetramethylammonium hydroxide, and the combination of TMAOCl and AcOH effectively promoted the C–C bond cleavage in a two-phase system without additional phase-transfer reagents. Unstrained tert-cycloalkanols were transformed into ω-chloroalkyl aryl ketones in moderate to excellent yields under metal-free and mild reaction conditions.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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