Organizing activities of axial mesoderm

Curr Top Dev Biol. 2024;157:83-123. doi: 10.1016/bs.ctdb.2024.02.007. Epub 2024 Mar 15.ABSTRACTFor almost a century, developmental biologists have appreciated that the ability of the embryonic organizer to induce and pattern the body plan is intertwined with its differentiation into axial mesoderm. Despite this, we still have a relatively poor understanding of the contribution of axial mesoderm to induction and patterning of different body regions, and the manner in which axial mesoderm-derived information is interpreted in tissues of changing competence. Here, with a particular focus on the nervous system, we review the evidence that axial mesoderm notochord and prechordal mesoderm/mesendoderm act as organizers, discuss how their influence extends through the different axes of the developing organism, and describe how the ability of axial mesoderm to direct morphogenesis impacts on its role as a local organizer.PMID:38556460 | DOI:10.1016/bs.ctdb.2024.02.007

Source: Current Topics in Developmental Biology - March 31, 2024 Category: Biology Authors: Elizabeth Manning Marysia Placzek Source Type: research