Electrochemical-induced solvent-tuned selective C(sp < sup > 3 < /sup > )-H bond activation towards the synthesis of C3-functionalized chromone derivatives

Chem Commun (Camb). 2024 Apr 18. doi: 10.1039/d4cc00919c. Online ahead of print.ABSTRACTAn unprecedented solvent-tuned electrochemical method for selective C(sp3)-H bond activation towards the synthesis of C3 functionalized chromone derivatives has been developed. This electrosynthesis protocol provides an efficient and green way to access various C3-functionalized chromones by avoiding traditionally employed transition metals and high temperatures. The swappable chemoselectivity was controlled mainly by altering the solvent and the current. A plausible reaction mechanism has been proposed with the help of radical capture and cyclic voltammetry experiments.PMID:38634308 | DOI:10.1039/d4cc00919c

Source: Chemical Communications - April 18, 2024 Category: Chemistry Authors: Ying Gao Mingxu Wang Jingxian Sun Xiao-Jing Zhao Yonghui He Source Type: research