Peak plasma anti-Xa direct oral anticoagulant levels after gastrointestinal surgeries: A retrospective cohort

Direct oral anticoagulants (DOACs) are first line treatment for venous thromboembolism (VTE) and non-valvular atrial fibrillation [1]. Absorption of DOACs may be decreased in patients with prior surgery involving removal or rearrangement of the proximal GI tract, due to bypassing absorptive surfaces, changes to gastric emptying, or altered acidity [2]. Decreased DOAC absorption may result in a lower anticoagulant effect and therefore increased risk of thrombosis. Plasma DOAC levels can be tested, but no validated therapeutic ranges exist [3].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research