Ketoreductase-catalyzed dynamic reductive kinetic resolution of sterically hindered 2-aryl-1,5-benzothiazepin-3,4(2H,5H)-diones: asymmetric synthesis of a key diltiazem precursor and its analogues

Green Chem., 2024, Accepted Manuscript DOI: 10.1039/D4GC01478B, PaperZijun Guo, Zexin Wu, Xiaofan Wu, Li Zhang, Zedu Huang, Fener Chen Owing to its associated advantages such as generation of two stereocenters in 100% maximum theoretical yield, mild reaction conditions and environmentally friendliness, ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) is... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - Category: Chemistry Authors: Source Type: research