Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages

Signaling via Notch receptors intrinsically regulates tumor cells, promoting tumor progression. Mandula et al. examine the impact of Notch ligands on cancer cells on anti-tumor immunity in lung cancer and find that deletion of Jagged2 promotes expansion of immunostimulatory macrophages and anti-tumor T cell immunity. Mechanistically, in the absence of Jagged2, the Notch ligand DLL1/4 on tumor cells rewires macrophages via Notch-mediated induction of the transcription factor IRF4.

Source: Immunity - April 17, 2024 Category: Allergy & Immunology Authors: Jay K. Mandula, Rosa A. Sierra-Mondragon, Rachel V. Jimenez, Darwin Chang, Eslam Mohamed, Shiun Chang, Julio A. Vazquez-Martinez, Yu Cao, Carmen M. Anadon, Sae Bom Lee, Satyajit Das, L éo Rocha-Munguba, Vincent M. Pham, Roger Li, Ahmad A. Tarhini, Muhamm Tags: Article Source Type: research