Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

Amino acid substitutions can perturb protein activity in multiple ways. Understanding their mechanistic basis may pinpoint how residues contribute to protein function. Here, we characterize the mechanisms unde...

Source: Genome Biology - April 16, 2024 Category: Genetics & Stem Cells Authors: Sarah Gersing, Thea K. Schulze, Matteo Cagiada, Amelie Stein, Frederick P. Roth, Kresten Lindorff-Larsen and Rasmus Hartmann-Petersen Tags: Research Source Type: research