Dihydrostilbenes from < em > Macaranga javanica < /em > (Blume) M üll. Arg. and their antiplasmodial activity

Nat Prod Res. 2024 Apr 17:1-7. doi: 10.1080/14786419.2024.2342555. Online ahead of print.ABSTRACTAn undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.PMID:38629185 | DOI:10.1080/14786419.2024.2342555

Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Tjitjik Srie Tjahjandarie Muhammad Fajar Aldin Ratih Dewi Saputri Mulyadi Tanjung Source Type: research