Genome-wide association study identified five quantitative trait loci and two candidate genes for digestive traits in Suhuai pigs

Anim Genet. 2024 Apr 15. doi: 10.1111/age.13430. Online ahead of print.ABSTRACTThis work aimed to identify markers and candidate genes underlying porcine digestive traits. In total, 331 pigs were genotyped by 80 K Chip data or 50 K Chip data. For apparent neutral detergent fiber digestibility, a total of 19 and 21 candidate single nucleotide polymorphisms (SNP) were respectively identified using a genome-wide efficient mixed-model association algorithm and linkage-disequilibrium adjusted kinship. Among them, three quantitative trait locus (QTL) regions were identified. For apparent acid detergent fiber digestibility, a total of 16 and 17 SNPs were identified by these two methods, respectively. Of these, three QTL regions were also identified. Moreover, two candidate genes (MST1 and LATS1), which are functionally related to intestinal homeostasis and health, were detected near these significant SNPs. Taken together, our results could provide a basis for deeper research on digestive traits in pigs.PMID:38618678 | DOI:10.1111/age.13430

Source: Animal Genetics - April 15, 2024 Category: Genetics & Stem Cells Authors: Kaijun Li Liming Hou Taoran Du Guang Pu Chenxi Liu Gensheng Liu Juan Zhou Ruihua Huang Qingbo Zhao Pinghua Li Source Type: research