Phenolic constituents from the branches of < em > Viburnum chinshanense < /em > as potential < em > α < /em > -amylase and < em > α < /em > -glucosidase inhibitory agents

Nat Prod Res. 2024 Apr 15:1-7. doi: 10.1080/14786419.2024.2341306. Online ahead of print.ABSTRACTThis paper reports the isolation of two undescribed phenolic glycosides (1 and 2), together with seven known compounds (3-9) from the branches of Viburnum chinshanense. The structures of undescribed compounds were elucidated by comprehensive spectroscopic methods (1D NMR, 2D NMR, and HRESIMS). The sugar units of compounds 1 and 2 were identified by acid hydrolysis and HPLC analysis of the chiral derivatives of the monosaccharides. Furthermore, the α‑amylase and α-glucosidase inhibitory activities of all isolates were evaluated and compounds 1, 5, and 8 displayed potential α‑amylase and α-glucosidase inhibitory activities. The molecular docking analyses of compounds 1 and 8 with the potent inhibition towards the target enzymes were also performed.PMID:38619012 | DOI:10.1080/14786419.2024.2341306

Source: Natural Product Research - April 15, 2024 Category: Biochemistry Authors: Hong-Juan Zhou Meng-Ya Yang Jia Chen Wei Ji Jian-Hua Shao Zi-Han Wang Chun-Chao Zhao Source Type: research