Molecules, Vol. 29, Pages 1790: Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized & beta;-Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles

Molecules, Vol. 29, Pages 1790: Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized β-Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles Molecules doi: 10.3390/molecules29081790 Authors: Yongchao Wang Yu Chen Shengli Duan Yiyang Cao Wenjin Sun Mei Zhang Delin Zhao Donghua Hu Jianwei Dong A chemselective catalyst-free three-component 1,3-dipolar cycloaddition has been described. The unique polycyclic THPI and THIQs were creatively employed as dipolarophiles, which led to the formation of functionalized β-tetrahydrocarboline- and tetrahydroisoquinoline-fused spirooxindoles in 60–94% of yields with excellent diastereoselectivities (10: 1−>99: 1 dr). This reaction not only realizes a concise THPI- or THIQs-based 1,3-dipolar cycloaddition, but also provides a practical strategy for the construction of two distinctive spirooxindole skeletons.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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