Pararorine A, isoindolinone alkaloid from the endophytic fungus Paramyrothecium roridum and its anti-tumor activity

Fitoterapia. 2024 Apr 10;175:105931. doi: 10.1016/j.fitote.2024.105931. Online ahead of print.ABSTRACTPararorine A, a new isoindolinone alkaloid was isolated from Paramyrothecium roridum, an endophytic fungus from the medicinal plant Gynochthodes officinalis (F.C. How) Razafim. & B. Bremer. The structure of this compound was elucidated by extensive spectroscopic (UV, IR, MS, and NMR) analyses. In addition, the antitumor activity of pararorine A was evaluated against SF-268, MCF-7, HepG2, and A549 tumor cell lines. The results revealed that pararorine A exhibited potent antitumor activities with the IC50 values ranging from 1.69 to 8.95 μM. Moreover, the tumor cell inhibitory activity of pararorine A was evidenced by promoting cytochrome C release and cell cycle arrest as well as the induction of apoptosis by the up-regulation of the protein expressions of JNK and Bax through PARP-cleavage and caspase 3-cleavage.PMID:38608733 | DOI:10.1016/j.fitote.2024.105931

Source: Fitoterapia - April 12, 2024 Category: Biochemistry Authors: Yuchan Chen Hongxin Liu Nuoyi Wang Haibo Tan Weimin Zhang Source Type: research