Irpexols A-C, xanthone derivatives from the endophyte fungus Irpex laceratus A878

Fitoterapia. 2024 Apr 11:105952. doi: 10.1016/j.fitote.2024.105952. Online ahead of print.ABSTRACTThree new xanthone derivatives irpexols A-C (1-3) and five known xanthones including three dimeric ones were successfully isolated from Irpex laceratus A878, an endophytic fungus of the family Irpicaceae from the medicinal plant Pogostemon cablin (Blanco) Bentham (Lamiaceae). The structures of these compounds were elucidated by extensive spectroscopic analyses includingultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), and nuclear magnetic resonance (NMR). All of the three new compounds (1-3) share a de-aromatic and highly‑oxygenated xanthone skeleton. In addition, the cytotoxic activity of compounds 1-8 were evaluated against SF-268, MCF-7, HepG2, and A549 tumor cell lines. The results revealed that compound 6 showed moderate cytotoxic activity with the IC50 values ranging from 24.83 to 45.46 μM, while the IC50 values of the positive control adriamycin was ranging from 1.11 to 1.44 μM.PMID:38614405 | DOI:10.1016/j.fitote.2024.105952

Source: Fitoterapia - April 13, 2024 Category: Biochemistry Authors: Yuchan Chen Nuoyi Wang Weipeng Ma Wei Gu Zihuan Sang Haibo Tan Weimin Zhang Hongxin Liu Source Type: research