Research progress of fullerenes and their derivatives in the field of PDT

Eur J Med Chem. 2024 Apr 7;271:116398. doi: 10.1016/j.ejmech.2024.116398. Online ahead of print.ABSTRACTIn contemporary studies, the predominant utilization of C60 derivatives pertains to their role as photosensitizers or agents that scavenge free radicals. The intriguing coexistence of these divergent functionalities has prompted extensive investigation into water-soluble fullerenes. The photodynamic properties of these compounds find practical applications in DNA cleavage, antitumor interventions, and antibacterial endeavors. Consequently, photodynamic therapy is progressively emerging as a pivotal therapeutic modality within the biomedical domain, owing to its notable levels of safety and efficacy. The essential components of photodynamic therapy encompass light of the suitable wavelength, oxygen, and a photosensitizer, wherein the reactive oxygen species generated by the photosensitizer play a pivotal role in the therapeutic mechanism. The remarkable ability of fullerenes to generate singlet oxygen has garnered significant attention from scholars worldwide. Nevertheless, the limited permeability of fullerenes across cell membranes owing to their low water solubility necessitates their modification to enhance their efficacy and utilization. This paper reviews the applications of fullerene derivatives as photosensitizers in antitumor and antibacterial fields for the recent years.PMID:38614061 | DOI:10.1016/j.ejmech.2024.116398

Source: European Journal of Medicinal Chemistry - April 13, 2024 Category: Chemistry Authors: Xue Bai Chungeng Dong Xinle Shao Faiz-Ur Rahman Huifang Hao Yongmin Zhang Source Type: research