Augmented ERO1 α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11

The dysregulated mechanistic target of rapamycin complex 1 (mTORC1) signaling plays a critical role in ferroptosis resistance and tumorigenesis. However, the precise underlying mechanisms still need to be full...

Source: Journal of Experimental and Clinical Cancer Research - April 13, 2024 Category: Cancer & Oncology Authors: Zixi Wang, Huaiyuan Zong, Weiwei Liu, Wei Lin, Anjiang Sun, Zhao Ding, Xu Chen, Xiaofeng Wan, Yanyan Liu, Zhongdong Hu, Hongbing Zhang, Hongwu Li, Yehai Liu, Dapeng Li, Sumei Zhang and Xiaojun Zha Tags: Research Source Type: research