Reaction mechanism catalyzed by the dissimilatory sulfite reductase. The role of the siroheme-[4FeS4] cofactor

In this study we use a large cluster model containing siroheme-[4Fe4S] cofactor and protein residues involved in the direct interactions with the substrate, to get insight into the most feasible reaction mechanism and to understand the role of each considered active site component. In combination with earlier studies reported in the literature, our results lead to several interesting insights. One of the most important conclusions is that the reaction mechanism consists of three steps of two-electron reduction of sulfur and the probable role of the siroheme-[4Fe4S] cofactor is to ensure the delivery of packages of two electrons to the reactant.PMID:38602444 | DOI:10.1002/cphc.202400327

Source: Chemphyschem - April 11, 2024 Category: Chemistry Authors: Anna W ójcik-Augustyn A Johannes Johansson Tomasz Borowski Source Type: research