Carbon 14 and Carbon 13 Syntheses of Velagliflozin

The oral solution of velagliflozin, SENVELGO, is the first liquid once daily, orally administered prescription medication to treat cats with diabetes. The detailed synthesis of carbon 14 – and carbon 13–labeled velagliflozin is described. ABSTRACTVelagliflozin is the active ingredient of the first oral liquid medication approved by the Food and Drug Administration for the treatment of diabetes in cats. This compound belongs to the known class of sodium-glucose cotransporter 2 inhibitors approved to treat diabetes in human. Here, we report the detailed synthesis of velagliflozin labeled with carbon 14 and carbon 13.
Source: Journal of Labelled Compounds and Radiopharmaceuticals - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research