Significance of filamin A in mTORC2 function in glioblastoma

Conclusions:
Our results support FLNA as a new downstream effector of mTORC2 controlling GBM cell motility. This new mTORC2-FLNA signaling pathway plays important roles in motility and invasion of glioblastoma cells.

Source: Molecular Cancer - July 2, 2015 Category: Cancer & Oncology Authors: Naphat ChantaravisootPiriya WongkongkathepJoseph LooPaul MischelFuyuhiko Tamanoi Source Type: research