Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins

J Physiol. 2024 Apr 10. doi: 10.1113/JP283829. Online ahead of print.ABSTRACTTwo-pore channels and TRP mucolipins are ubiquitous endo-lysosomal cation channels of pathophysiological relevance. Both are Ca2+-permeable and regulated by phosphoinositides, principally PI(3,5)P2. Accumulating evidence has uncovered synergistic channel activation by PI(3,5)P2 and endogenous metabolites such as the Ca2+ mobilizing messenger NAADP, synthetic agonists including approved drugs and physical cues such as voltage and osmotic pressure. Here, we provide an overview of this coordination.PMID:38598430 | DOI:10.1113/JP283829

Source: The Journal of Physiology - April 10, 2024 Category: Physiology Authors: Yu Yuan Dawid Ja ślan Taufiq Rahman Franz Bracher Christian Grimm Sandip Patel Source Type: research