Severe leptospirosis in tropical and non-tropical areas: A comparison of two french, multicentre, retrospective cohorts

by J érôme Allyn, Arnaud-Félix Miailhe, Benjamin Delmas, Lucas Marti, Nicolas Allou, Julien Jabot, Jean Reignier BackgroundLeptospirosis is an anthropozoonosis that occurs worldwide but is more common in tropical regions. Severe forms may require intensive care unit (ICU) admission. Whether the clinical patterns and outcomes differ between tropical and non-tropical regions with similar healthcare systems is unclear. Our objective here was to address this issue by comparing two cohorts of ICU patients with leptospirosis managed in mainland France and in the overseas French department of R éunion, respectively. Methodology/Principal findingsWe compared two retrospective cohorts of patients admitted to intensive care for severe leptospirosis, one from Reunion Island in the Indian Ocean (tropical climate) and the other from metropolitan France (temperate climate). Chi-square and Student ’s t tests were used for comparisons. After grouping the two cohorts, we also performed multiple correspondence analysis and hierarchical clustering to search for distinct clinical phenotypes. The Réunion and Metropolitan France cohorts comprised 128 and 160 patients respectively. Compared with t he Réunion cohort, the metropolitan cohort had a higher mean age (42.5±14.1 vs. 51.4±16.5 years, p
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research