FOXO1 is a master regulator of memory programming in CAR T cells

Nature, Published online: 10 April 2024; doi:10.1038/s41586-024-07300-8The transcription factor FOXO1 has a key role in human T cell memory, and manipulating FOXO1 expression could provide a way to enhance CAR T cell therapies by increasing CAR T cell persistence and antitumour activity.

Source: Nature AOP - April 10, 2024 Category: Research Authors: Alexander E. Doan Katherine P. Mueller Andy Y. Chen Geoffrey T. Rouin Yingshi Chen Bence Daniel John Lattin Martina Markovska Brett Mozarsky Jose Arias-Umana Robert Hapke In-Young Jung Alice Wang Peng Xu Dorota Klysz Gabrielle Zuern Malek Bashti Patrick J Source Type: research