Ligand efficacy modulates conformational dynamics of the µ-opioid receptor

Nature, Published online: 10 April 2024; doi:10.1038/s41586-024-07295-2Studies on the µ-opioid receptor using fluorescent labelling of intracellular residues and energy transfer experiments in the presence of different ligands with or without G-protein binding reveals conformational changes that correlate to ligand efficacy.

Source: Nature AOP - April 10, 2024 Category: Research Authors: Jiawei Zhao Matthias Elgeti Evan S. O ’Brien Cec ília P. Sár Amal EI Daibani Jie Heng Xiaoou Sun Elizabeth White Tao Che Wayne L. Hubbell Brian K. Kobilka Chunlai Chen Source Type: research