Methodology for awakening the potential secondary metabolic capacity in actinomycetes

Abstract
Secondary metabolites produced by actinomycete strains undoubtedly have great potential for use in applied research areas such as drug discovery. However, it is becoming difficult to obtain novel compounds because of repeated isolation around the world. Therefore, a new strategy for discovering novel secondary metabolites is needed. Many researchers believe that actinomycetes have as yet unanalyzed secondary metabolic activities, and the associated undiscovered secondary metabolite biosynthesis genes are called “silent” genes. This review outlines several approaches to further activate the metabolic potential of actinomycetes.

Beilstein J. Org. Chem. 2024, 20, 753–766. doi:10.3762/bjoc.20.69

Source: Beilstein Journal of Organic Chemistry - April 10, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: actinomycete co-culture heat shock metabolites (HSMs) secondary metabolites silent genes Review Source Type: research