Electrochemical dual oxidative C(sp < sup > 3 < /sup > )-H amination: switchable synthesis of imidazo-fused quinazolinones

Chem Commun (Camb). 2024 Apr 9. doi: 10.1039/d4cc00994k. Online ahead of print.ABSTRACTAn efficient electrochemical dual C(sp3)-H amination was developed under metal-free and chemical oxidant-free conditions. A series of imidazo[1,5-a]quinazolin-5(4H)-ones and 5-oxo-4,5-dihydroimidazo[1,5-a]quinazoline-3-carbonitriles can be obtained in high yields and the product distribution can be modulated by virtue of this method. The reaction mechanism was investigated and the corresponding intermediates were studied. The reaction features a broad substrate scope, regulation of the product distribution, mild conditions and scalable preparation.PMID:38591991 | DOI:10.1039/d4cc00994k

Source: Chemical Communications - April 9, 2024 Category: Chemistry Authors: Chengbin Du Yan Zhang Tong Li Zhenggen Zha Zhiyong Wang Source Type: research