SDF-1/CXCR4 axis participants in the pathophysiology of adult patients with moyamoya disease

Moyamoya disease (MMD) is characterized by an abundance of moyamoya vessels; however, the precise mechanism driving the spontaneous angiogenesis of these compensatory vessels remains unclear. Previous research has established a link between the stromal cell-derived factor-1 (SDF-1)/ CXC receptor 4 (CXCR4) axis and angiogenesis under hypoxic conditions. Nevertheless, the alterations in this axis within the cerebrospinal fluid, arachnoid membranes and vascular tissue of MMD patients have not been fully investigated.

Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2024 Category: Neurology Authors: Shuaiyu Ren, Qingdong Han, Peng Zhou, Zongqi Wang, Yabo Huang Source Type: research