B cell characteristics define HCV reinfection outcome

In individuals highly exposed to hepatitis C virus (HCV), reinfection is common, suggesting that natural development of sterilising immunity is difficult. In those that are reinfected, some will develop a persistent infection, while a small proportion repeatedly clear the virus, suggesting natural protection is possible. The aim of this study was to characterise immune responses associated with rapid natural clearance of HCV reinfection.

Source: Journal of Hepatology - April 9, 2024 Category: Gastroenterology Authors: Alexander P. Underwood, Money Gupta, Bing-Ru Wu, Auda A. Eltahla, Irene Boo, Jing Jing Wang, David Agapiou, Arunasingam Abayasingam, Arnold Reynaldi, Elizabeth Keoshkerian, Yanran Zhao, Nicholas Brasher, Melanie R. Walker, Jens Bukh, Lisa Maher, Tom Gordo Tags: Research Article Source Type: research