Extended blood stage sensitivity profiles of < em > Plasmodium cynomolgi < /em > to doxycycline and tafenoquine, as a model for < em > Plasmodium vivax < /em >

Antimicrob Agents Chemother. 2024 Apr 8:e0028024. doi: 10.1128/aac.00280-24. Online ahead of print.ABSTRACTTesting Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed death effect induced by doxycycline [IC50(96 h), 1,401 ± 607 nM]. As expected, IC50(96 h) to chloroquine (20.4 nM), piperaquine (12.6 µM), and tafenoquine (1,424 nM) were not affected by extended exposure.PMID:38587391 | DOI:10.1128/aac.00280-24

Source: Antimicrobial Agents and Chemotherapy - April 8, 2024 Category: Microbiology Authors: Peter Christensen Rosy Cinzah Rossarin Suwanarusk Adeline Chiew Yen Chua Osamu Kaneko Dennis E Kyle Htin Lin Aung Jessica Matheson Pablo Bifani Laurent R énia Gregory M Cook Georges Snounou Bruce Russell Source Type: research