Acceleration of hydrolytic ring opening of N7-alkylguanine by the terminal carbamoyl group of glycidamide

Chem Commun (Camb). 2024 Apr 5. doi: 10.1039/d3cc04997c. Online ahead of print.ABSTRACTHydrolytic ring opening of guanine N7-adducts with compounds containing an oxacyclopropane ring, namely glycidamide, glycidol and 1,2-epoxybutane, was analyzed, and the reaction of the glycidamide adduct was the fastest. The differences in the reaction rates were confirmed by theoretical calculations.PMID:38577847 | DOI:10.1039/d3cc04997c

Source: Chemical Communications - April 5, 2024 Category: Chemistry Authors: Shigenori Iwai Yuta Hayashi Tomohiro Baba Yasutaka Kitagawa Source Type: research