Highly substituted benzo[ < em > b < /em > ]furan synthesis through substituent migration

Chem Commun (Camb). 2024 Apr 5. doi: 10.1039/d4cc01192a. Online ahead of print.ABSTRACTAn unusual benzofuran synthesis from 2,6-disubstituted phenols and alkynyl sulfoxides is disclosed. Various highly substituted benzofurans were synthesized via the charge-accelerated [3,3]-sigmatropic rearrangement and subsequent substituent migration. Multiaryl-substituted benzofurans and fully substituted benzofurans were prepared on the basis of the unique reaction mechanism.PMID:38578172 | DOI:10.1039/d4cc01192a

Source: Chemical Communications - April 5, 2024 Category: Chemistry Authors: Akihiro Kobayashi Shinya Tabata Suguru Yoshida Source Type: research