Cytotoxicity phenylpropanoid amides from the seed of < em > Cannabis sativa < /em > L

Nat Prod Res. 2024 Apr 8:1-8. doi: 10.1080/14786419.2024.2338800. Online ahead of print.ABSTRACTTwo novel phenylpropanoid amides, namely huomarenamide A (1) and huomarenamide B (2), along with twelve known compounds (3-14), were isolated from the seeds of Cannabis sativa L. The structures with absolute configurations of new compounds were unequivocally determined by spectroscopic analyses and the ECD method. The identification of the known compounds was based on a comparison of their 1D NMR data with literature references. All compounds were assessed for cytotoxic activity against LN229 cells, revealing that compounds 2, 13, and 14 exhibited significant cytotoxicity with IC50 values ranging from 9.02 to 21.26 μM.PMID:38587148 | DOI:10.1080/14786419.2024.2338800

Source: Natural Product Research - April 8, 2024 Category: Biochemistry Authors: Ao-Fei Wang Juan Pan Xiang Liu Xin-Yuan Li Peng Jiang Meng-Meng Li Wei Guan Qing-Shan Chen Li-Li Zhang Hai-Xue Kuang Yan Liu Bing-You Yang Source Type: research