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Efforts aimed at gaining insight into the genetic architecture of complex-trait disorders turn, with increasing frequency, to rare-variant association studies (RVASs). Indeed, in recent years, many methods have been developed to detect rare variants that influence human traits. The increase in large-scale sequencing studies suggests that like genome-wide association studies (GWASs), which study the association between common variants and complex phenotypes, successful implementation of RVASs might rely on the integration of data obtained from multiple groups.

Source: The American Journal of Human Genetics - July 2, 2015 Category: Genetics & Stem Cells Authors: Sarah Ratzel, Sara B. Cullinan Tags: Editors’ Corner Source Type: research