Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review

ConclusionAvailable information suggests that the anatomical and physiological changes throughout pregnancy may have meaningful effects on the PK of mAbs. For most mAbs (not IFX), modestly higher dosing (per mg) maybe needed during pregnancy to sustain a similar serum exposure compared to pre-pregnancy.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research