The role of soluble adenylyl cyclase in sensing and regulating intracellular pH

Pflugers Arch. 2024 Apr 6. doi: 10.1007/s00424-024-02952-x. Online ahead of print.ABSTRACTSoluble adenylyl cyclase (sAC) differs from transmembrane adenylyl cyclases (tmAC) in many aspects. In particular, the activity of sAC is not regulated by G-proteins but by the prevailing bicarbonate concentrations inside cells. Therefore, sAC serves as an exquisite intracellular pH sensor, with the capacity to translate pH changes into the regulation of localization and/or activity of cellular proteins involved in pH homeostasis. In this review, we provide an overview of literature describing the regulation of sAC activity by bicarbonate, pinpointing the importance of compartmentalization of intracellular cAMP signaling cascades. In addition, examples of processes involving proton and bicarbonate transport in different cell types, in which sAC plays an important regulatory role, were described in detail.PMID:38581526 | DOI:10.1007/s00424-024-02952-x

Source: Pflugers Archiv : European Journal of Physiology - April 6, 2024 Category: Physiology Authors: Hang Lam Li Arthur Verhoeven Ronald Oude Elferink Source Type: research