The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection

Anaerobe. 2024 Mar 27:102842. doi: 10.1016/j.anaerobe.2024.102842. Online ahead of print.ABSTRACTLate anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.PMID:38552897 | DOI:10.1016/j.anaerobe.2024.102842

Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Isaura Rigo Mary K Young Mayuresh M Abhyankar Feifan Xu Girija Ramakrishnan Farha Naz William A Petri Gregory R Madden Source Type: research