Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury

CONCLUSION: Loss of WWOX function in ECs is associated with a heightened inflammatory response during mechanical stretch that is associated with increased MAPK phosphorylation and appears to be dependent on upregulation of zyxin.PMID:38563965 | DOI:10.1152/ajplung.00277.2023

Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Zhenguo Zeng Eltyeb Abdelwahid Weiguo Chen Christian Ascoli Trinh Pham Jeffrey R Jacobson Steven M Dudek Viswanathan Natarajan C Marcelo Aldaz Roberto F Machado Sunit Singla Source Type: research