Copper(I)-free syntheses of [ < sup > 11 < /sup > C/ < sup > 18 < /sup > F]trifluoromethyl ketones from alkyl or aryl esters and [ < sup > 11 < /sup > C/ < sup > 18 < /sup > F]fluoroform

Chem Commun (Camb). 2024 Apr 5. doi: 10.1039/d4cc00465e. Online ahead of print.ABSTRACTHerein, we report a copper(I)-free method for labeling the trifluoroacetyl group with positron-emitting carbon-11 (t1/2 = 20.4 min) or fluorine-18 (t1/2 = 109.8 min) as part of our exploration of radiolabeled fluoroforms to access new radiolabeled chemotypes of interest for tracer development. Treatment of alkyl esters and aryl esters, containing electron-donating or electron-withdrawing groups, with [11C/18F]fluoroform in the presence of strong base, gave [11C/18F]trifluoromethyl ketones as novel radiolabeling synthons in moderate to high yields within 15 minutes.PMID:38577766 | DOI:10.1039/d4cc00465e
Source: Chemical Communications - Category: Chemistry Authors: Source Type: research
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