FEN1-assisted DNA logic amplifier circuit for fast and compact DNA computing

Chem Commun (Camb). 2024 Apr 5. doi: 10.1039/d4cc00203b. Online ahead of print.ABSTRACTThis work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest and compact DNA computing. Moreover, the logic circuit can use input strands with concentrations of less than 1 nM, which is more than 100 times lower than the input concentration of other DNA logic circuits, providing a promising methodology for constructing fast and compact DNA computations.PMID:38577866 | DOI:10.1039/d4cc00203b

Source: Chemical Communications - April 5, 2024 Category: Chemistry Authors: Zheng Xiang Jia-Yi Zheng Xueping Ma Yanan Chu Qinxin Song Guohua Zhou Bingjie Zou Haiping Wu Chen Wang Source Type: research