Polyploidisation pleiotropically buffers ageing in hepatocytes

Polyploidy in hepatocytes has been proposed as a genetic mechanism to buffer against transcriptional dysregulation. Here, we aim to demonstrate the role of polyploidy in modulating gene regulatory networks in hepatocytes during ageing.

Source: Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Kelvin Yin, Maren B üttner, Ioannis K. Deligiannis, Mateusz Strzelecki, Liwei Zhang, Carlos Talavera-López, Fabian Theis, Duncan T. Odom, Celia P. Martinez-Jimenez Tags: Research Article Source Type: research